What is Orfadin prescribed for?

Orfadin is prescribed for the treatment of hereditary tyrosinemia type 1, a rare pediatric disease causing progressive liver failure and liver cancer in young children. It is used along with a diet restricting the amino acids tyrosine and phenylalanine.

Warnings for People taking Orfadin:

Patients and their parents or caregivers should tell their doctor right away about:

• any unexplained eye symptoms (eye pain, redness, swelling or burning of the eyes)
• rash
• jaundice (yellowing of the skin and whites of the eyes, and dark color to the urine)
• excessive bleeding

There are some things that you should tell your Doctor including:

• Tell your doctor if you are pregnant, trying to get pregnant, or if you are currently breast feeding.
• Tell your doctor if you are allergic to nitisinone (Orfadin) or to any of the other ingredients in Orfadin.
• Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

What side effects can you expect when taking Orfadin? (This is only a partial list of side effects reported with Orfadin. Ask your doctor or pharmacist for a complete list of possible side effects and drug interactions..)

The most common side effects of Orfadin were related to high tyrosine levels due to patients not eating the right foods as well as rare cases of a decrease in platelet and white blood cell counts.

For more detailed information about Orfadin, ask your doctor or pharmacist.